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<b> Title and abstract screening </b><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios">1. Is it a study investigating SNI, CCI or PSL animal models of neuropathic pain? Include, if unclear.</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios">2. Is the experiment conducted in <i>in vivo</i> mice (mus musculus) or <i>in vivo</i> rats (rattus norvegicus forma domestica) or both? Include, if unclear.</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios">3. Is the study an original primary research article? Include, if unclear. </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<b> Full text screening </b>
<!-- Multiple Radios -->
<br>
<br>
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.</b> Is the study an <i>in vivo</i> animal study with SNI, PSL or CCI model of neuropathic pain?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.</b> Is there at least one pain-related behavioural assessment reported in the study?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.</b> Are there at least TWO times of assessment?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>4.</b> Is the study an original primary research article? (No review, no book chapters, no congress abstracts) </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<b>Experimental design</b>
<br>
<br>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>1.</b> Which species was used in this study?</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
Mice (mus musculus)
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
Rat (rattus norvegicus forma domestica)
</label>
</div>
<div class="checkbox">
<label for="checkboxes-2">
<input type="checkbox" name="checkboxes" id="checkboxes-2" value="3">
Both
</label>
</div>
</div>
</div>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>2.</b> Which strain(s) was/were used in this study?</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
C57BL6J
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
C57BL6J
</label>
</div>
<div class="checkbox">
<label for="checkboxes-2">
<input type="checkbox" name="checkboxes" id="checkboxes-2" value="3">
C57Bl6N
</label>
</div>
<div class="checkbox">
<label for="checkboxes-3">
<input type="checkbox" name="checkboxes" id="checkboxes-3" value="4">
SD
</label>
</div>
<div class="checkbox">
<label for="checkboxes-4">
<input type="checkbox" name="checkboxes" id="checkboxes-4" value="5">
Swiss
</label>
</div>
<div class="checkbox">
<label for="checkboxes-5">
<input type="checkbox" name="checkboxes" id="checkboxes-5" value="6">
CD-1
</label>
</div>
<div class="checkbox">
<label for="checkboxes-6">
<input type="checkbox" name="checkboxes" id="checkboxes-6" value="7">
Wistar
</label>
</div>
<div class="checkbox">
<label for="checkboxes-7">
<input type="checkbox" name="checkboxes" id="checkboxes-7" value="8">
IAF hairless
</label>
</div>
<div class="checkbox">
<label for="checkboxes-8">
<input type="checkbox" name="checkboxes" id="checkboxes-8" value="9">
Long evans
</label>
</div>
<div class="checkbox">
<label for="checkboxes-9">
<input type="checkbox" name="checkboxes" id="checkboxes-9" value="10">
Lewis
</label>
</div>
<div class="checkbox">
<label for="checkboxes-10">
<input type="checkbox" name="checkboxes" id="checkboxes-10" value="11">
Sabra
</label>
</div>
</div>
</div>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>3.</b> Was the age of the animals reported?</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
Yes
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Text input-->
<ul style="list-style-type:NONE"><li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>3a.</b> If yes, please extract the age in days</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div>
</div></li></ul>
<br>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>4.</b> Which control group was used?
<br>
<i> Multiple options can apply if more than one control group was chosen</i></label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
vehicle control with induced neuropathic pain model
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
vehicle control with sham surgery
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
vehicle control without any surgery
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
induced neuropathic pain model without vehicle
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
sham surgery without vehicle
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
naive control
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
collateral side control
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
other
</label>
</div>
</div>
</div>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>5.</b> Was the model duration reported?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div>
<!-- Text input-->
<ul style="list-style-type:NONE"><li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>5.1</b> If yes, please specify the duration of the model (from induction to euthanasia)</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div>
</div></li></ul>
<br>
<!-- Text input-->
<div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>6</b> How many time points were assessed?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div>
</div>
<br>
<!-- Text input-->
<div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>7</b> How many time points >= post-operative day 7 were reported?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div>
</div>
<br>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>8.</b> Select the pain-associated behaviours assessed</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
evoked: mechanical stimulus
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
evoked: heat stimulus
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-2" value="3">
evoked: cold stimulus
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-3" value="4">
evoked: electric stimulus
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-4" value="5">
non-evoked - nocifensive (e.g. grimacing)
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-5" value="6">
movement-evoked (e.g.gait analysis)
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-6" value="7">
non-evoked - elective (e.g. social behavior, nest building)
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-7" value="8">
non-evoked - survival (e.g. grooming, feeding)
</label>
</div>
</div>
</div>
<b> Neuropathic pain induction</b>
<br>
<br>
<!-- Select Basic --><div class="form-group"><label class="col-md-4 control-label" for="selectbasic"><b>1.</b> Procedure label: What is the type of neuropathic pain model? </label>
<div class="col-md-4"><select id="selectbasic" name="selectbasic" class="form-control">
<option value="1">SNI/Spared Nerve Injury- Decosterd_Woolf_2000</option>
<option value="2">PSL or PSNL/ Partial Sciatic Nerve Ligation</option>
<option value="3">CCI/Chronic Constriction Injury (all variants)</option>
</select><em><span class="help-block">List the disease or injury that is being modelled; Provide a label to uniquely identify a disease model induction procedure within the study </span></em></div>
</div><br>
<!-- Select Basic -->
<div class="form-group"><label class="col-md-4 control-label" for="selectbasic"><b>2.</b> Was one of the following anaesthetics used? </label>
<div class="col-md-4"><select id="selectbasic" name="selectbasic" class="form-control">
<option value="1">Isoflurane</option>
<option value="2">KetamineL</option>
<option value="3">Ketamine/Xylazine</option>
<option value="4">Others</option>
<option value="5">Not reported</option>
</select>
</div>
</div>
<!-- Text input-->
<ul style="list-style-type:NONE">
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>2.1</b> If others, please specify the substance from the study text</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div>
</div></li></ul>
<br>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>3.</b> Was pre-operative analgesia administered?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label> <em><span class="help-block"> </span></em></div>
</div>
<!-- Text input-->
<ul style = "list-style-type:NONE">
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>3.1</b> If yes, which analgesic drug was used?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the substance from the study text </span></em></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>3.2</b> If yes, at which dosage (in mg/kg bodyweight) was the analgesic administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>3.3</b> If yes, how many times was the analgesic drug administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>3.4</b> If yes, which drug application route was used?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> i.p. </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> i.v. </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> s.c. </label> <label class="radio-inline" for="radios-3"> <input type="radio" name="radios" id="radios-3" value="4" /> i.t. </label> <label class="radio-inline" for="radios-4"> <input type="radio" name="radios" id="radios-4" value="5" /> Others </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>3.5</b> If others, please specify the route from the study text</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the route from the study text </span></em></div>
</div></li>
</ul>
<br>
<div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>4.</b> Was peri-operative analgesia administered?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label> <em><span class="help-block"> </span></em></div>
</div>
<ul style="list-style-type:NONE">
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>4.1</b> If yes, Which analgesic drug was used?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the substance from the study text </span></em></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>4.2</b> If yes, at which dosage (in mg/kg bodyweight) was the analgesic administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>4.3</b> If yes, How many times was the analgesic drug administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>4.4</b> If yes, Which drug application route was used?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> i.p. </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> i.v. </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> s.c. </label> <label class="radio-inline" for="radios-3"> <input type="radio" name="radios" id="radios-3" value="4" /> i.t. </label> <label class="radio-inline" for="radios-4"> <input type="radio" name="radios" id="radios-4" value="5" /> Others </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>4.5</b> If others, please specify the route from the study text</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /></div>
</div></li></ul>
<br>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>5.</b> Was post-operative analgesia administered?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label> </div>
</div>
<ul style="list-style-type:NONE">
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput">
<b>5.1</b> If yes, What analgesic drug was used?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the substance from the study text </span></em></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>5.2</b> If yes, at which dosage (in mg/kg bodyweight) was the analgesic administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>5.3</b> If yes, How many times was the analgesic drug administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>5.4</b> If yes, Which drug application route was used?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> i.p. </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> i.v. </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> s.c. </label> <label class="radio-inline" for="radios-3"> <input type="radio" name="radios" id="radios-3" value="4" /> i.t. </label> <label class="radio-inline" for="radios-4"> <input type="radio" name="radios" id="radios-4" value="5" /> Others </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>5.5</b> If others, please specify the route from the study text</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the route from the study text </span></em></div>
</div></li>
</ul>
<br>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>6.</b> Was antibiotica administered peri-operatively or post-operatively?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label> <em><span class="help-block"></span></em></div>
</div>
<ul style="list-style-type:NONE">
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>6.1</b> If yes, Which antibiotica was used?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the anitbiotica from the study text </span></em></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>6.2</b> If yes, at which dosage (in mg/kg bodyweight) was the analgesic administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>6.3</b> If yes, How many times was the antibiotica administered?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>6.4</b> If yes, Which application route was used?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> i.p. </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> i.v. </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> s.c. </label> <label class="radio-inline" for="radios-3"> <input type="radio" name="radios" id="radios-3" value="4" /> i.t. </label> <label class="radio-inline" for="radios-4"> <input type="radio" name="radios" id="radios-4" value="5" /> Others </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>6.5</b> If others, please specify the route from the study text</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block">Please specify the route from the study text </span></em></div>
</div></li>
</ul>
<br>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>7.</b> Did the authors specify how many ligations were made in the CCI model?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label> <em><span class="help-block">The number does not matter. </span></em></div>
</div>
<ul style="list-style-type:NONE">
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>7.1</b> If yes, How many ligatures were added to the CCI model?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>7.2</b> If yes, which material was used for the ligatures?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
</ul>
<!-- Multiple Radios (inline) -->
<br>
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>8.</b> Was the the skin incision dimension described in cm?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div>
<ul style="list-style-type:NONE">
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>8.1</b> If yes, How long was the skin incision in cm?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" />
</div>
</div>
</li>
</ul>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>9.</b> Was the tissue closure procedure described?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div>
<ul style="list-style-type:NONE">
<!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>9.1</b> If yes, Was the muscular layer closed?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<ul style="list-style-type:NONE">
<!-- Select Basic -->
<li><div class="form-group"><label class="col-md-4 control-label" for="selectbasic"><b>9.1.1</b> If yes, what suture material was used to close the muscle layer? </label>
<div class="col-md-4"><select id="selectbasic" name="selectbasic" class="form-control">
<option value="1">Resorbable suture</option>
<option value="2">Non-absorbable suture</option>
<option value="3">Others</option>
</select><em><span class="help-block"> </span></em></div>
</div></li>
</ul>
<!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>9.2</b> If yes, Was the skin layer closed?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div>
<ul style="list-style-type:NONE">
<!-- Select Basic -->
<li><div class="form-group"><label class="col-md-4 control-label" for="selectbasic"><b>9.2.1</b> If yes, what suture material was used to close the muscle layer? </label>
<div class="col-md-4"><select id="selectbasic" name="selectbasic" class="form-control">
<option value="1">Resorbable suture</option>
<option value="2">Non-absorbable suture</option>
<option value="3">Tissue glue</option>
<option value="4">Staples</option>
<option value="5">Others</option>
</select><em><span class="help-block"> </span></em></div>
</div></li>
</ul>
<br>
</li>
</ul>
<!-- Multiple Radios (inline) -->
<div class="form-group"><label class="col-md-4 control-label" for="radios"><b>10.</b> Were the skin sutures removed?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div>
<ul style="list-style-type:NONE"><!-- Multiple Radios (inline) -->
<li><div class="form-group"><label class="col-md-4 control-label" for="radios"><b>10.1</b> If yes, were an anaesthic given?</label>
<div class="col-md-4"><label class="radio-inline" for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked" /> Yes </label> <label class="radio-inline" for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2" /> No </label> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<!-- Text input-->
<li><div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>10.2</b> On which postoperative day were the sutures removed?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div></li>
<br>
</ul>
<br>
<!-- Text input-->
<div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>11.</b>How long was the operative experience of the surgeon <b>in months</b>?</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <label class="radio-inline" for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3" /> Not reported </label></div>
</div>
<html>
<b>Assessment of sex as a biological variable in an individual study</b><br>
<b> A: Basic reporting, contextualization </b>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.</b> Does the study report sex of experimental animals in title or abstract?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.</b> Does the study report sex of animals in the main manuscript? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Multiple Radios (inline)-->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1</b>If yes, is it a single-sex study? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
<ul style="list-style-type:NONE">
<!-- Multiple Radios (inline)-->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1.1 </b> If yes:</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Male
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
Female
</label>
</div>
</div>
</div>
</li>
<!-- Multiple Radios -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1.2</b> If yes, Is the reason to include animals from only one sex reported?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div></div></li>
<ul style="list-style-type:NONE">
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>2.1.2.1</b> If yes, please, quote. (Leave blank if not reported)</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li>
</ul>
<!-- Multiple Radios -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1.3</b> If yes, are limitations in single-sex studies discussed? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
<ul style="list-style-type:NONE">
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>2.1.3.1</b> If yes, please quote. (Leave blank if not reported)</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li></ul>
<!-- Multiple Radios -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1.4</b> If yes, did authors consider it interesting to investigate the effect of treatment in both sexes in follow-up research?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div></li><br>
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1.5</b> If no, did authors highlight a sex difference in the title?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div></li><br>
</ul>
</ul>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.</b> Does the study cite earlier studies in reference to the existence (or lack) of significant differences between males and females? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>4.</b> Does the study consider whether the mechanism under investigation is present in both sexes? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>5.</b> Does the study reflect on important sex-specific epidemiologic distributions in neuropathic pain prevalence in the human population?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>5.1</b> If yes, please, quote.</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div></li></ul><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>6.</b> Does the study reflect on the potential sex-bias in pre-existing evidence?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div><br>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>7.</b> Did the authors use the term “sex” or “gender”?</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
used “sex” only
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
used “gender” only
</label>
</div>
<div class="checkbox">
<label for="checkboxes-2">
<input type="checkbox" name="checkboxes" id="checkboxes-2" value="3">
used both terms
</label>
</div>
<div class="checkbox">
<label for="checkboxes-3">
<input type="checkbox" name="checkboxes" id="checkboxes-3" value="4">
used neither terms
</label>
</div>
</div>
</div>
<br<br><br>
<b>B: covariates / environment</b>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.</b> Do the author consider hormonal status of rodents to be an important covariate?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Multiple Checkboxes -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>1.1</b> If yes, do they consider it important to consider hormonal status in</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
Female rodents
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
Male rodents
</label>
</div>
</div>
</div>
</li>
<!-- Multiple Radios -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.2</b> Was hormonal status assessed during the experiments?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
<ul style="list-style-type:NONE">
<!-- Multiple Checkboxes -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>1.2.1</b> A method to measure hormonal status is described for: </label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
Female rodents
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
Male rodents
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-2" value="3">
None
</label>
</div>
</div>
</div>
</li>
</ul></ul>
<br>
<!-- Multiple Checkboxes -->
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>2.</b> Additional experimental groups were added to assess the influence of: </label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
gonadal hormones
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
chromosomes
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-2" value="3">
ovarioectomy/castration
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-3" value="4">
pregnancy/pseudo-pregnancy
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-4" value="5">
no additional experimental groups added to investigate effect of gonadal hormones or chromosomes
</label>
</div>
</div>
</div>
<br>
<!--- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.</b> Was the number of male or female animals per cage described? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes, female or male animal number per cage was reported
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No, animals per cage were reported but not sex-specific
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
No reporting of animals per cage
</label>
</div>
</div>
<!-- Textarea -->
<ul style="list-style-type:NONE"><li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>3.1</b> If yes, how many male rodents were housed per cage? </label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li>
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>3.2</b> If yes, how many female rodents were housed per cage? </label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li>
</ul>
<br>
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>4.</b> Was the experimenter sex reported </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<br/>
<b>C: study design</b>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios">
<b>1.</b> Did the study have a factorial design with sex as a factor?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Textarea -->
<ul style="list-style-type:NONE">
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>1.1</b> If yes, state the design (group level x factor level) </label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li>
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>1.2</b> If no, describe the design</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div></li>
</ul><br>
<!--for studies with 3 = Not applicable, questions on study design do not need to get answered-->
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2</b>. Was the sample size specified for females and male rodents separately? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>2.1</b> If yes, female rodents per group (as planned): </label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div></li>
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>2.2</b> If yes, male rodents per group (as planned): </label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div></li>
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>2.3</b> If no, total number of animals per group:</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div></li>
</ul>
<br>
<!-- Textarea -->
<div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>3.</b> Extract the statistical analysis used for analysis of pain-associated behavioural assessment (e.g. ANOVA-type analysis, mixed-effect models) </label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
<br>
<!-- Textarea -->
<div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>4.</b> Extract any statistical tests used to compare female and male animals' outcomes</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>5.</b> Did the authors report to power for an interaction effect? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>6.</b> Did the authors consider that their study design might lack power to detect interactions (with significance criterium)? </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<br>
<b>D: statistical analysis </b><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.</b> Were animals of both sexes pooled for the analysis?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radio-0" value="2">
A: analyzed sex separately at least for some pain-associated behavioural assessment analysis
</label>
</div>
<label for="radio-1">
<input type="radio" name="radios" id="radio-1" value="3">
B: pooled for all pain-associated behavioural assessment analysis
</label>
</div>
</div>
<ul style = "list-style-type: NONE">
<li><div class = "form-group">
<label class = "col-md-4 control-label" for= "radios"><b>1.1</b> If A, which approach was used?</label>
<div class = "col-md-4">
<div class = "radio">
<label for= "radios-0">
<input type = "radio" name = "radios" id = "radio-0" value = "1">
analyzed separatedly after finding no difference in testing for interaction
</label>
</div>
<div class = "radio">
<label for= "radios-1">
<input type = "radio" name = "radios" id = "radio-1" value = "2">
analyzed separatedly without testing for interaction
</label>
</div>
<div class = "radio">
<label for= "radios-0">
<input type = "radio" name = "radios" id = "radio-0" value = "3">
analyzed separatedly after finding significant interaction effect
</label>
</div>
</div>
</div>
</li>
<!--Multiple Radios-->
<li><div class = "form-group">
<label class = "col-md-4 control-label" for= "radios"><b>1.2</b> If B, which approach was used?</label>
<div class = "col-md-4">
<div class = "radio">
<label for= "radios-0">
<input type = "radio" name = "radios" id = "radio-0" value = "1" checked = "checked">
pooled after finding not difference in testing for interaction
</label>
</div>
<div class = "radio">
<label for= "radios-0">
<input type = "radio" name = "radios" id = "radio-1" value = "2" checked = "checked">
pooled without testing for interaction
</label>
</div>
<div class = "radio">
<label for= "radios-0">
<input type = "radio" name = "radios" id = "radio-2" value = "3" checked = "checked">
pooled after finding significant interaction effect
</label>
</div>
</div>
</div>
</li>
</ul>
<br>
<b>E: Results reporting</b>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1. </b> Does the study report sex-disaggregated data in graphs, tables, or raw data for pain-associated behavioural test?</label>
<div class = "col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.</b> Are pain-associated behavioral assessment outcomes described for both female and male animals?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.</b> Are pain-associated behavioral assessment outcomes compared between female and male animals?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<ul style = "list-style-type: NONE">
<li>
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.1</b> Results are described as: </label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Differing between male and female animals
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
Not differing between male and female animals
</label>
</div>
</div>
</div>
</li>
<li>
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.2</b> Results are labelled "significant" or "not significant" in reference to a statistical testing procedure:</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
<ul style = "list-style-type: NONE">
<li>
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.2.1</b> If yes, was the a statistical testing procedure to compare results between males and females described?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
<ul style = "list-style-type: NONE">
<li>
<!-- Text input-->
<div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>2.2.1.1</b> If yes, please specify the testing procedure:</label>
<div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div>
</div>
</li>
</ul>
</ul>
</ul>
<b>Risk of bias assessment</b><br><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.</b> Were the ARRIVE guidelines followed?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.</b> Were the animals randomly assigned to the experimental group?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Multiple Radios -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.1</b> If yes, has the method of randomization been reported?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
</ul>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>3.</b> Was the group assignment concealed to the investigator?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Textarea -->
<div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>3.1</b> If yes, please quote. (Leave blank if not reported)</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</ul>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>4.</b> Were the animal caretakers and investigators conducting the experiments blinded to the allocation sequence?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>5.</b> Were the investigators blinded to the assessment, measurement or quantifying the experimental outcome?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>6.</b> Was a priori sample size calculation performed?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<li><!-- Textarea -->
<div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>6.1</b> If yes, please quote (incl. the method)</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li></ul>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>7.</b> Were rules for stopping data collection defined in advance?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>8.</b> Have any excluded animals been reported?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>8.1</b> If yes, was attrition reported separately for sex?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
</li>
</ul>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>9.</b> Were definition and handling of outliers defined a priori in the study design/methods section?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
<div class="radio">
<label for="radios-2">
<input type="radio" name="radios" id="radios-2" value="3">
Not reported
</label>
</div>
</div>
</div>
<br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>10.</b> Was the funding source reported?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<ul style="list-style-type:NONE">
<li>
<div class="form-group">
<label class="col-md-4 control-label" for="checkboxes"><b>10.1</b> If yes, categorize the source of funding</label>
<div class="col-md-4">
<div class="checkbox">
<label for="checkboxes-0">
<input type="checkbox" name="checkboxes" id="checkboxes-0" value="1">
public funding
</label>
</div>
<div class="checkbox">
<label for="checkboxes-1">
<input type="checkbox" name="checkboxes" id="checkboxes-1" value="2">
industry funding
</label>
</div>
</div>
</div>
</li>
<!-- Textarea -->
<li><div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>10.2 </b> If yes, please extract the name of the funder(s).</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
</li>
</ul>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>11.</b> Was a conflict of interest reported?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes, conflict of interest was reported
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
Yes, it was reported that no conflict of interest existed
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-2" value="3">
No conflict-of-interest-statement included
</label>
</div>
</div>
</div><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>12.</b> Was the research project pre-registered?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div>
<b>Research context</b><br><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>1.</b>Was the name of first author indicative of female gender?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div><br>
<!-- Multiple Radios -->
<div class="form-group">
<label class="col-md-4 control-label" for="radios"><b>2.</b> Was the name of last author indicative of female gender?</label>
<div class="col-md-4">
<div class="radio">
<label for="radios-0">
<input type="radio" name="radios" id="radios-0" value="1" checked="checked">
Yes
</label>
</div>
<div class="radio">
<label for="radios-1">
<input type="radio" name="radios" id="radios-1" value="2">
No
</label>
</div>
</div>
</div><br>
<!-- Textarea -->
<div class="form-group">
<label class="col-md-4 control-label" for="textarea"><b>3.</b> Please extract country affiliaton of last author</label>
<div class="col-md-4">
<textarea class="form-control" id="textarea" name="textarea"></textarea>
</div>
</div>
