<link href="//maxcdn.bootstrapcdn.com/bootstrap/4.1.1/css/bootstrap.min.css" rel="stylesheet" id="bootstrap-css"> <script src="//maxcdn.bootstrapcdn.com/bootstrap/4.1.1/js/bootstrap.min.js"></script> <script src="//cdnjs.cloudflare.com/ajax/libs/jquery/3.2.1/jquery.min.js"></script> <!------ Include the above in your HEAD tag ----------> <b>B: covariates / environment</b> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>1.</b> Do the author consider hormonal status of rodents to be an important covariate?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <ul style="list-style-type:NONE"> <!-- Multiple Checkboxes --> <li><div class="form-group"> <label class="col-md-4 control-label" for="checkboxes"><b>1.1</b> If yes, do they consider it important to consider hormonal status in</label> <div class="col-md-4"> <div class="checkbox"> <label for="checkboxes-0"> <input type="checkbox" name="checkboxes" id="checkboxes-0" value="1"> Female rodents </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-1" value="2"> Male rodents </label> </div> </div> </div> </li> <!-- Multiple Radios --> <li><div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>1.2</b> Was hormonal status assessed during the experiments?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> </li> <ul style="list-style-type:NONE"> <!-- Multiple Checkboxes --> <li><div class="form-group"> <label class="col-md-4 control-label" for="checkboxes"><b>1.2.1</b> A method to measure hormonal status is described for: </label> <div class="col-md-4"> <div class="checkbox"> <label for="checkboxes-0"> <input type="checkbox" name="checkboxes" id="checkboxes-0" value="1"> Female rodents </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-1" value="2"> Male rodents </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-2" value="3"> None </label> </div> </div> </div> </li> </ul></ul> <br> <!-- Multiple Checkboxes --> <div class="form-group"> <label class="col-md-4 control-label" for="checkboxes"><b>2.</b> Additional experimental groups were added to assess the influence of: </label> <div class="col-md-4"> <div class="checkbox"> <label for="checkboxes-0"> <input type="checkbox" name="checkboxes" id="checkboxes-0" value="1"> gonadal hormones </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-1" value="2"> chromosomes </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-2" value="3"> ovarioectomy/castration </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-3" value="4"> pregnancy/pseudo-pregnancy </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-4" value="5"> no additional experimental groups added to investigate effect of gonadal hormones or chromosomes </label> </div> </div> </div> <br> <!--- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>3.</b> Was the number of male or female animals per cage described? </label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes, female or male animal number per cage was reported </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No, animals per cage were reported but not sex-specific </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> No reporting of animals per cage </label> </div> </div> <!-- Textarea --> <ul style="list-style-type:NONE"><li><div class="form-group"> <li><label class="col-md-4 control-label" for="textarea"><b>3.1</b> If yes, how many male rodents were housed per cage? </label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </li> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>3.2</b> If yes, how many female rodents were housed per cage? </label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div></li> </ul> <br> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>4.</b> Was the experimenter sex reported </label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </ul> <br> <b>C: study design</b> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>1.</b> Did the study have a factorial design with sex as a factor?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <!-- Textarea --> <ul style="list-style-type:NONE"><li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>1.1</b> If yes, state the design (group level x factor level) </label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </li> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>1.2</b> If no, describe the design</label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div></li> </ul><br> <!--for studies with 3 = Not applicable, questions on study design do not need to get answered--> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>2</b>. Was the sample size specified for females and male rodents separately? </label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <ul style="list-style-type:NONE"> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>2.1</b> If yes, female rodents per group (as planned): </label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div></li> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>2.2</b> If yes, male rodents per group (as planned): </label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div></li> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>2.3</b> If no, total number of animals per group:</label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div></li> </ul> <br> <!-- Textarea --> <div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>3.</b> Extract the statistical analysis used for analysis of pain-associated behavioural assessment (e.g. ANOVA-type analysis, mixed-effect models) </label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div> <br> <!-- Textarea --> <div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>4.</b> Extract any statistical tests used to compare female and male animals' outcomes</label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div> <br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>5.</b> Did the authors report to power for an interaction effect? </label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>6.</b> Did the authors consider that their study design might lack power to detect interactions (with significance criterium)? </label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <br> <b>D: statistical analysis </b><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>1.</b> Were animals of both sexes pooled for the analysis?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radio-0" value="2"> A: analyzed sex separately at least for some pain-associated behavioural assessment analysis </label> </div> <label for="radio-1"> <input type="radio" name="radios" id="radio-1" value="3"> B: pooled for all pain-associated behavioural assessment analysis </label> </div> </div> <ul style = "list-style-type: NONE"> <li><div class = "form-group"> <label class = "col-md-4 control-label" for= "radios"><b>1.1</b> If A, which approach was used?</label> <div class = "col-md-4"> <div class = "radio"> <label for= "radios-0"> <input type = "radio" name = "radios" id = "radio-0" value = "1"> analyzed separatedly after finding no difference in testing for interaction </label> </div> <div class = "radio"> <label for= "radios-1"> <input type = "radio" name = "radios" id = "radio-1" value = "2"> analyzed separatedly without testing for interaction </label> </div> <div class = "radio"> <label for= "radios-0"> <input type = "radio" name = "radios" id = "radio-0" value = "3"> analyzed separatedly after finding significant interaction effect </label> </div> </div></div> </li> <!--Multiple Radios--> <li><div class = "form-group"> <label class = "col-md-4 control-label" for= "radios"><b>1.2</b> If B, which approach was used?</label> <div class = "col-md-4"> <div class = "radio"> <label for= "radios-0"> <input type = "radio" name = "radios" id = "radio-0" value = "1" checked = "checked"> pooled after finding not difference in testing for interaction </label> </div> <div class = "radio"> <label for= "radios-0"> <input type = "radio" name = "radios" id = "radio-1" value = "2" checked = "checked"> pooled without testing for interaction </label> </div> <div class = "radio"> <label for= "radios-0"> <input type = "radio" name = "radios" id = "radio-2" value = "3" checked = "checked"> pooled after finding significant interaction effect </label> </div> </div> </ul> <br> <b>E: Results reporting</b> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>1. </b> Does the study report sex-disaggregated data in graphs, tables, or raw data for pain-associated behavioural test?</label> <div class = "col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>2.</b> Are pain-associated behavioral assessment outcomes described for both female and male animals?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>3.</b> Are pain-associated behavioral assessment outcomes compared between female and male animals?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <ul style = "list-style-type: NONE"> <li> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>3.1</b> Results are described as: </label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Differing between male and female animals </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> Not differing between male and female animals </label> </div> </div> </div> </li> <li> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>3.2</b> Results are labelled "significant" or "not significant" in reference to a statistical testing procedure:</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> </li> <ul style = "list-style-type: NONE"> <li> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>2.2.1</b> If yes, was the a statistical testing procedure to compare results between males and females described?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> </li> <ul style = "list-style-type: NONE"> <li> <!-- Text input--> <div class="form-group"><label class="col-md-4 control-label" for="textinput"><b>2.2.1.1</b> If yes, please specify the testing procedure:</label> <div class="col-md-4"><input id="textinput" name="textinput" type="text" placeholder=" " class="form-control input-md" /> <em><span class="help-block"></span></em></div> </div> </li> </ul> </ul> </ul>